Apis mellifica or mellifera is a homeopathic remedy prepared from the honey bee, a well known insect of the Hymenoptera family. The immediate response to honeybee venom is also well known: local stitching pain, inflammation, redness and swelling of the area and anaphylactic reactions. These effects seemingly involve the inhibition of the peripheral cholinergic neurotransmitter system. More recent studies suggest a deeper level of action, reaching even the level of DNA fragmentation.
Signs and symptoms of multiple stings include urticaria (hives), nausea, vomiting, diarrhea, hypotension, confusion, seizures, and renal failure. Mass inoculation of bee venom may induce acute renal failure (ARF), adult respiratory distress syndrome, liver injury, cardiac damage, pancreatitis, skin necrosis, shock hypertension, bleeding, thrombocytopenia, hemolysis, and rhabdomyolysis.
Animal studies have shown a decrease in glomerular filtration rate and urinary volume after bee venom infusion. In the same way, venom caused a sharp and immediate decrease in renal blood flow.
Apis in acute conditions
Homeopathically, Apis is one of the main remedies for a well-defined picture inflammatory edema – mostly, but not necessarily, of allergic nature: light red or pink hued, affecting large surfaces, irradiating heat and usually not pruriginous. Because of its similarity in aspect and pathophysiological processes, Apis is probably the most indicated in allergic conditions like angioneurotic, or Quincke edema
Case illustration of a characteristic Apis allergic edema.
The patient, known with an Allergic asthma in childhood, treated with homeopathy, was bitten by an insect and in few minutes he developed a huge edema all over the body, including face, lips, eyelids and ears.
The form of antimony found in nature is stibine, stibnite, or antimonite (Sb2S3). Intoxication in exposed subjects manifests as respiratory (lung inflammation, chronic bronchitis, asthma, acute pulmonary edema), gastrointestinal (abdominal pain, diarrhea, vomiting and ulcers) and skin disorders. Dermatitis associated with exposure to airborne antimony is characterized by epidermal cellular necrosis with associated acute inflammatory cellular reactions. Women exposed to antimony in the workplace have reported menstrual disturbances and a higher incidence of abortions. Although in Homeopathy, the pathogenetic profile of antimony has been enlarged, these remain the main organic affinities.
There is no homeopathic proving of pure antimony – Antimonium metallicum ; to have an idea of its effects, we may extrapolate from the symptoms common to its most used and time-verified salts – Antimonium crudum (black sulphide, Sb2S3) and Antimonium tartaricum (a complex salt of potassium). We have large experience with the homeopathic preparation of the native salt, Antimonite – chemically identical to Ant-c – especially in skin disorders, observing both curative and pathogenetic effects, which may be added to compose the image of the antimony root.
The most common sign of Antimony remedies in the materia medica is vesicular eruptions.
Their occurrence and characteristics could be confirmed through the involuntary proving made by a 11 month-old infant, who was prescribed Antimonite due to recurrent bronchial spasms and muscular hypotonia:
Antimonite: Small, isolated vesicles on a congestive base. Vesicles are filled with clear fluid
and depressed in the center, as in chicken-pox.